Triethylamine → 3-Isoxazolamine, 5-(1,1-dimethylethyl)-
Reaction equation
[C:1]([CH2:7][C:8]#[N:9])(=[O:6])[C:2]([CH3:5])([CH3:4])[CH3:3].C([N:12](CC)CC)C.S(O)(O)(=O)=O.NO>O>[NH2:9][C:8]1[CH:7]=[C:1]([C:2]([CH3:5])([CH3:4])[CH3:3])[O:6][N:12]=1Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
A suspension of pivaloylacetonitrile (12.52 g) and triethylamine (11.27 g) in water (200 ml) is stirred and mixed with hydroxylamine sulfate (9.03 g). pH 8.22. The reaction mixture is treated as in Example 2 to give 3-amino-5-t-butylisoxazole (11.45 g; yield, 81.7%).
Workup
- additionThe reaction mixture is treated as in Example 2
Sources & evidence
- ORD record
- ord-d73c023895844ceaa0b5ec960b928bde
- Source dataset
- uspto-grants-1981_03
- Patent number
- US04256899
Reaction notes
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