Diethyl benzylphosphonate → Benzylphosphonic Acid

HRID 1277168

Reaction equation

HRID 1277168 reaction equation
[CH2:1]([P:8](=[O:15])([O:12]CC)[O:9]CC)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>CO.Cl>[CH2:1]([P:8](=[O:9])([OH:15])[OH:12])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 1

HCID 14122Diethyl benzylphosphonate

Product 1

HCID 81312Benzylphosphonic AcidYield 59.2%

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 887MethanolSolvent

Procedure

A solution of diethyl benzylphosphonate (25 g) in methanol (10 ml) and concentrated hydrochloric acid (500 ml) solution was refluxed for 4 days. The mixture was cooled to room temperature, and precipitated crystal was collected by filtration to give benzylphosphonic acid (11.17 g) as colorless crystals.

Workup

  1. customprecipitated crystal
  2. filtrationwas collected by filtration

Sources & evidence

ORD record
ord-5596f6c3590a4af082eeb7279cd3958f
Source dataset
uspto-grants-2000_12
Patent number
US06166006

Linked notes

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