Pyridine → HCID 12922684, compound

HRID 1277916

Reaction equation

HRID 1277916 reaction equation
[P:1](=[O:7])([NH2:6])([S:4][CH3:5])[O:2][CH3:3].N1C=CC=CC=1.Cl[S:15][N:16]([CH:23]([CH3:25])[CH3:24])[C:17](=[O:22])[O:18][CH2:19][CH2:20][CH3:21].Cl.N1C=CC=CC=1.S(Cl)Cl>C(Cl)Cl>[CH2:19]([O:18][C:17]([N:16]([CH:23]([CH3:24])[CH3:25])[S:15][NH:6][P:1](=[O:7])([S:4][CH3:5])[O:2][CH3:3])=[O:22])[CH2:20][CH3:21]

Participants

7

Reactant 5

HCID 1049PyridineHCID 4096MethamidophosHCID 25353Sulfur dichloride2×HCID 10176127Pyridinium chlorideHCID 12922683Propyl (chlorosulfenyl)(isopropyl)carbamate

Product 1

HCID 12922684HCID 12922684, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a stirred mixture of 4.0 g (0.028 mol) O,S-dimethyl phosphoramidothioate, 2.2 g pyridine (0.028 mol) and 15 ml of anhydrous methylene chloride, chilled to 0°-5° C., was added dropwise 6.0 g (0.028 mol) propyl (chlorosulfenyl)(isopropyl)carbamate over a period of 15 minutes. Pyridine hydrochloride forms immediately during addition of the sulfenyl chloride. The reaction mixture was stirred for an additional half hour at room temperature after the addition of the sulfenyl chloride.

Workup

  1. temperaturechilled to 0°-5° C.

Sources & evidence

ORD record
ord-c35fd00e208c42c198d6462c8173f4f0
Source dataset
uspto-grants-1981_07
Patent number
US04279897

Linked notes

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