Dimethylformamide dimethyl acetal → 3-Dimethylamino-1-(6-methyl-2-pyridyl)-2-propen-1-one

HRID 1278237Notes

Reaction equation

HRID 1278237 reaction equation
[C:1]([C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([CH3:10])[N:5]=1)(=[O:3])[CH3:2].CO[CH:13](OC)[N:14]([CH3:16])[CH3:15]>>[CH3:13][N:14]([CH3:16])[CH:15]=[CH:2][C:1]([C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([CH3:10])[N:5]=1)=[O:3]

Participants

3

Reactant 2

HCID 78373Dimethylformamide dimethyl acetalHCID 1388722-Acetyl-6-methylpyridine

Product 1

HCID 538801933-Dimethylamino-1-(6-methyl-2-pyridyl)-2-propen-1-one

Procedure

A mixture of 25.0 g of 2-acetyl-6-methylpyridine and 35 ml. of N,N-dimethylformamide dimethylacetal is refluxed for 16 hours. The mixture is cooled and filtered to give 3-dimethylamino-1-(6-methyl-2-pyridyl)-2-propen-1-one as crystals, m.p. 97°-98° C.

Workup

  1. temperatureThe mixture is cooled
  2. filtrationfiltered

Sources & evidence

ORD record
ord-6a557c30da95423492744838b3851c84
Source dataset
uspto-grants-1981_07
Patent number
US04281000

Reaction notes

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