Hydrochloric Acid → 2-Methyl-2-(4-methylphenyl)propanoic acid
Reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([CH3:12])([CH3:11])[C:9]#N)=[CH:4][CH:3]=1.[OH-:13].[Na+].C(O)C[O:17]CCO.Cl>O>[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([CH3:12])([CH3:11])[C:9]([OH:17])=[O:13])=[CH:4][CH:3]=1Participants
6
Procedure
A solution of 2-(4-methylphenyl)-2-methylpropionitrile (53.61 g), sodium hydroxide (40.4 g), diethylene glycol (160.8 ml) and water (60.6 ml) was refluxed for 18 hr. The reaction mixture was poured into water (3000 ml) and conc. hydrochloric acid (90 ml) was added. The generated crystals were collected by filtration to give the title compound (60.0 g) as pale-brown crystals, m.p.=78-81° C.
Workup
- additionwas added
- filtrationThe generated crystals were collected by filtration
Sources & evidence
- ORD record
- ord-0636ae7279c74635a7af00ce486818ba
- Source dataset
- uspto-grants-2002_09
- Patent number
- US06455528B1
Reaction notes
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