N-Methylaniline → N-Methylacetanilide

HRID 1283231

Reaction equation

HRID 1283231 reaction equation
[CH:1]([O:4]P(O)OC(C)C)(C)[CH3:2].[CH3:11][NH:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>>[CH3:11][N:12]([C:1](=[O:4])[CH3:2])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

Participants

3

Reactant 2

HCID 7515N-MethylanilineHCID 558181Dipropan-2-yl hydrogen phosphite

Product 1

HCID 11364N-MethylacetanilideYield 53%

Procedure

Example 34 was repeated, except that 0.05 mole of phosphorous diisopropyl ester was used in place of phosphorous monoethyl ester and 0.05 mole of N-methylaniline was used in place of aniline, to obtain N-methylacetanilide, yield 53% based on N-methylaniline.

Sources & evidence

ORD record
ord-70797182cb8c41a2aa756591bc4c352f
Source dataset
uspto-grants-1976_08
Patent number
US03974219

Linked notes

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