Salicylic Acid → 2-(Dichloromethyl)phenol
Reaction equation
[C:1](O)(=O)[C:2]1[C:3](=[CH:5][CH:6]=[CH:7][CH:8]=1)[OH:4].S(Cl)(Cl)=O.[Cl-:15].[Al+3].[Cl-:17].[Cl-]>>[CH:1]([Cl:17])([Cl:15])[C:2]1[C:3](=[CH:5][CH:6]=[CH:7][CH:8]=1)[OH:4]Participants
4
Conditions
- Temperature
- 42.5 °C
Procedure
A mixture of 10 grams salicylic acid, 7 ml of thionyl chloride, and 0.02 gram of aluminum chloride was heated at 40 to 45°C. for 11/2 hours. The excess thionyl chloride was removed in vacuum and the salicylyl chloride reaction product can be used without further purification.
Workup
- customThe excess thionyl chloride was removed in vacuum
- customthe salicylyl chloride reaction product
- customcan be used without further purification
Sources & evidence
- ORD record
- ord-3e83c12fe1db40ba8056d1044542bbe6
- Source dataset
- uspto-grants-1976_08
- Patent number
- US03975532
Reaction notes
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