Phosgene → Ethyl 2-chlorocarbonyloxyimino-2-cyanoacetate
Reaction equation
[OH:1][N:2]=[C:3]([C:9]#[N:10])[C:4]([O:6][CH2:7][CH3:8])=[O:5].C(N(CC)CC)C.[C:18](Cl)([Cl:20])=[O:19]>C1C=CC=CC=1>[Cl:20][C:18]([O:1][N:2]=[C:3]([C:9]#[N:10])[C:4]([O:6][CH2:7][CH3:8])=[O:5])=[O:19]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
In dry benzene (50 ml), ethyl 2-hydroxyimino-2-cyanoacetate (7.2 g) and triethylamine (7.0 ml) are dissolved, and the resulting solution is dropwise added to a solution of phosgene (0.05 mol) in benzene (52.5 ml) at 5°C. The mixture is stirred at the same temperature for 2 hours and allowed to stand at room temmperature over night to give a solution of ethyl 2-chlorocarbonyloxyimino-2-cyanoacetate.
Workup
- waitto stand at room temmperature over night
Sources & evidence
- ORD record
- ord-8450049bf4864cfaab28735617804860
- Source dataset
- uspto-grants-1976_08
- Patent number
- US03976635
Reaction notes
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