Ethyl formate → HCID 21515920, compound
Reaction equation
[F:1][C:2]([C:13]1[CH:20]=[CH:19][CH:18]=[CH:17][C:14]=1[CH2:15][NH2:16])([F:12])[C:3]([F:11])([F:10])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[CH:21](OCC)=[O:22]>>[F:1][C:2]([C:13]1[CH:20]=[CH:19][CH:18]=[CH:17][C:14]=1[CH2:15][NH:16][CH:21]=[O:22])([F:12])[C:3]([F:11])([F:10])[C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=1Participants
3
Procedure
2-(α,α,β,β-Tetrafluorophenethyl)benzylamine, 1.4 g. (0.005 mole), in 100 ml. of ethyl formate, is stirred and heated to refluxing for about 20 hours. Evaporation of the solution to dryness and trituration of the residual solid with petroleum ether gives N-[2-(α,α,β,β-tetrafluorophenethyl)benzyl]formamide, m.p. 61°-75°C.
Workup
- temperatureheated
- temperatureto refluxing for about 20 hours
- customEvaporation of the solution to dryness and trituration of the residual solid with petroleum ether