Hydrochloric Acid → 4-Methyl-1H-imidazole-5-carboxylic acid
Reaction equation
[OH-].[Na+].[CH3:3][C:4]1[NH:8][CH:7]=[N:6][C:5]=1[C:9]([O:11]CC)=[O:10].Cl>O>[CH3:3][C:4]1[NH:8][CH:7]=[N:6][C:5]=1[C:9]([OH:11])=[O:10]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
Sodium hydroxide (70.0 g, 1.75 moles), followed by ethyl 5-methyl-1H-imidazole-4-carboxylate (34.0 g, 0.22 mole), were added to 500 ml of water. The reaction mixture was stirred and heated at reflux for one hour, cooled in an ice bath, and neutralized with 150 ml of concentrated hydrochloric acid. The precipitated solid was collected and dried to give 5-methyl-1H-imidazole-4-carboxylic acid.
Workup
- temperatureheated
- temperatureat reflux for one hour
- temperaturecooled in an ice bath
- customThe precipitated solid was collected
- customdried
Sources & evidence
- ORD record
- ord-bf81dec674f3433a8f965bf21cfc7740
- Source dataset
- uspto-grants-1986_01
- Patent number
- US04565875
Reaction notes
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