Ethanol → 7-Ethyl-3-methyl-1H-indol-6-amine
Reaction equation
C(O)C.[H][H].[CH3:6][C:7]1[C:15]2[C:10](=[C:11]([CH2:19][CH3:20])[C:12]([N+:16]([O-])=O)=[CH:13][CH:14]=2)[NH:9][CH:8]=1>[Fe].C(O)(=O)C>[CH3:6][C:7]1[C:15]2[C:10](=[C:11]([CH2:19][CH3:20])[C:12]([NH2:16])=[CH:13][CH:14]=2)[NH:9][CH:8]=1Participants
6
Reactant 3
Product 1
Reagents, catalysts & solvents 2
Conditions
- Temperature
- 90 °C
Procedure
A mixture of 0.5 l of 96° ethanol, 0.5 l of glacial acetic acid and 100 g of hydrogen-reduced pure iron is heated to 90° C. 51 g of 3-methyl-6-nitro-7-ethylindole are added in portions over 15 minutes.
Sources & evidence
- ORD record
- ord-26b3eadcf140474993e9b1c9c1144a2d
- Source dataset
- uspto-grants-1998_05
- Patent number
- US05752982
Reaction notes
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