Dimethylformamide dimethyl acetal → HCID 72461143, compound

Reaction equation

[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([NH:10][C:11]([NH2:13])=[S:12])=[CH:6][CH:5]=1)([O-:3])=[O:2].CO[CH:16](OC)[N:17]([CH3:19])[CH3:18]>>[CH3:16][N:17]([CH:19]=[N:13][C:11]([NH:10][C:7]1[CH:8]=[CH:9][C:4]([N+:1]([O-:3])=[O:2])=[CH:5][CH:6]=1)=[S:12])[CH3:18]

Participants

Reactant 2

HCID 78373Dimethylformamide dimethyl acetal

HCID 2760234(p-Nitrophenyl)thiourea

Product 1

HCID 72461143HCID 72461143, compoundYield 74.3%

Conditions

Temperature: 100 °C

Procedure

A mixture of 5 g (25.3 mmol) (4-nitro-phenyl)-thiourea and 33.8 ml (253 mmol) N,N-Dimethylformamide dimethyl acetal was heated to 100° C. for 1 h. The precipitate was filtered off, washed with diethyl ether and dried to yield 4.74 g (74%) the title compound as orange solid.

Workup

filtrationThe precipitate was filtered off
washwashed with diethyl ether
customdried

Sources & evidence

ORD record: ord-5c7645bfdcac4a2c95db1e703ec8db1e
Source dataset: uspto-grants-2007_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07250431B2

Reaction notes

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