3-Pyridinecarboxaldehyde → HCID 22857565, compound

HRID 129753

Reaction equation

HRID 129753 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH:7]=O)[CH:2]=1.[NH2:9][C@@H:10]([C:13]([OH:15])=[O:14])[CH2:11][SH:12]>C(O)C>[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH:7]2[NH:9][C@@H:10]([C:13]([OH:15])=[O:14])[CH2:11][S:12]2)[CH:2]=1

Participants

4

Reactant 2

HCID 103713-PyridinecarboxaldehydeHCID 92851D-Cysteine

Product 1

HCID 22857565HCID 22857565, compoundYield 54%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 1.07 g of pyridine-3-aldehyde and 1.21 g of D-cysteine in 60% v/v aqueous ethanol was heated under reflux for 4 hours. The mixture was cooled to room temperature and the resulting solid material was removed by filtration. The filtrate was concentrated by evaporation under reduced pressure, and 5 ml of ethanol were added to the resulting residue. Collecting the precipitated crystals by filtration gave 1.13 g (yield 54%) of the title compound, melting at 138°-139° C.

Workup

  1. temperatureunder reflux for 4 hours
  2. customthe resulting solid material was removed by filtration
  3. concentrationThe filtrate was concentrated by evaporation under reduced pressure, and 5 ml of ethanol
  4. additionwere added to the resulting residue
  5. customCollecting the precipitated crystals
  6. filtrationby filtration

Sources & evidence

ORD record
ord-492bc5de6e494e6abeed9560618fc5f6
Source dataset
uspto-grants-1995_11
Patent number
US05470851

Linked notes

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