Cyclopropylamine → HCID 178516935, compound

Reaction equation

[CH:1]1([NH2:4])[CH2:3][CH2:2]1.[S:5]1[CH2:11][C:9](=[O:10])[NH:8][C:6]1=S.CCN(C(C)C)C(C)C>>[CH:1]1([NH:4][C:6]2[S:5][CH2:11][C:9](=[O:10])[N:8]=2)[CH2:3][CH2:2]1

Participants

Reactant 3

HCID 69828Cyclopropylamine

HCID 81531Diisopropylethylamine

HCID 1201546Rhodanine

Product 1

HCID 178516935HCID 178516935, compound

Procedure

Similar procedure as described in example 1f was used, starting cyclopropylamine, rhodanine (2-thioxo-thiazolin-4-one) and DIEA to give 2-cyclopropylamino-thiazol-4-one. LC-MS m/e 157 (MH+).

Sources & evidence

ORD record: ord-e2d89f88171f4d54b37c083df208bd2e
Source dataset: uspto-grants-2007_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07250515B2

Reaction notes

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