Morpholine → 4-(4-Trifluoromethylphenyl)morpholine
Reaction equation
C1COCCN1.FC(F)(F)c1ccc(Br)cc1>CC1=CC(C)=[O]->[Pd]2([O]1)[O]C(C)=CC(C)=[O]->2.CN(C)c1ccccc1P(C(C)(C)C)C(C)(C)C.COCCOCCOC.C[Si](C)(C)[O-].[Li+]>FC(F)(F)c1ccc(N2CCOCC2)cc1Participants
9
Reactant 2
Product 3
Reagents, catalysts & solvents 4
Conditions
- Temperature
- 60 °C
Workup
- customThe foil sealing tape was removed from the plate.
- addition3 μL of a 0.0667 M solution of caffeine in DMSO was added to each reaction well using an SPT Labtech Mosquito® liquid handling robot
- filtrationThe plates were then centrifuged for 15 to 20 seconds. · Keep liquid
- aliquotFollowing centrifugation, 500 nL of the resultant mixture from each well was carefully dispensed into four 384-well analytical plates (Analytical Sales # 38435) using an SPT Labtech Mosquito® liquid handling robot. Each well of these analytical plates contained 30 μL of DMSO with 0.1% acetic acid, pre-dosed by OpenTrons, to facilitate analysis.
Sources & evidence
- ORD record
- ord-6f8336f18c98408d95125bdd40d2b0d8
- Source dataset
- High-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions
- Original link
- View source
Reaction notes
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