4-Hydroxybenzaldehyde → 3-Chloro-4-(4-formylphenoxy)benzonitrile

HRID 130731Notes

Reaction equation

HRID 130731 reaction equation
[OH:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[CH:4][CH:3]=1.[Cl:10][C:11]1[CH:12]=[C:13]([CH:16]=[CH:17][C:18]=1F)[C:14]#[N:15]>>[Cl:10][C:11]1[CH:12]=[C:13]([CH:16]=[CH:17][C:18]=1[O:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[CH:4][CH:3]=1)[C:14]#[N:15]

Participants

3

Reactant 2

HCID 1264-HydroxybenzaldehydeHCID 1455253-Chloro-4-fluorobenzonitrile

Product 1

HCID 568514253-Chloro-4-(4-formylphenoxy)benzonitrileYield 1.91%

Procedure

The above compound is prepared by nucleophilic displacement reaction of 4-hydroxy benzaldehyde and 3-chloro-4-fluorobenzonitrile under basic conditions as described in Example 243, step 1.91% yield.

Sources & evidence

ORD record
ord-00ce6ab391e4482686748c3c97010fec
Source dataset
uspto-grants-2008_06
Patent number
US07381719B2

Reaction notes

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