Water → HCID 69214914, compound
Reaction equation
[Na].C[O:3][C:4]([C:6]1[C:14]2[C:13](=[O:15])[N:12]([CH3:16])[C:11](=[O:17])[N:10]([CH:18]([CH3:20])[CH3:19])[C:9]=2[S:8][C:7]=1[CH2:21][N:22]1[C:26]2[CH:27]=[CH:28][CH:29]=[CH:30][C:25]=2[N:24]=[C:23]1S(C)(=O)=O)=[O:5].[OH2:35]>>[O:35]=[C:23]1[N:22]([CH2:21][C:7]2[S:8][C:9]3[N:10]([CH:18]([CH3:20])[CH3:19])[C:11](=[O:17])[N:12]([CH3:16])[C:13](=[O:15])[C:14]=3[C:6]=2[C:4]([OH:3])=[O:5])[C:26]2[CH:27]=[CH:28][CH:29]=[CH:30][C:25]=2[NH:24]1Participants
4
Procedure
Sodium hydrogenocarbonate (0.55 g) was added to a suspension of the product from example 32 part b) (0.54 g) in water. The reaction mixture was heated at reflux for 17 h. The reaction mixture was washed with ethyl acetate and the aqueous layer was freezed dried to give the sub-title compound (0.7 g). MS(ES)(M++H) 415
Workup
- temperatureThe reaction mixture was heated
- temperatureat reflux for 17 h
- wash