Morpholine → 4-(4-Trifluoromethylphenyl)morpholine

Reaction equation

C1COCCN1.FC(F)(F)c1ccc(Br)cc1>CC(=O)[O][Pd][O]C(C)=O.CC(C)(C)[O-].CS(C)=O.N#CNC(=N)c1cccc(C(=N)NC#N)n1.[K+]>FC(F)(F)c1ccc(N2CCOCC2)cc1

customThe foil sealing tape was removed from the plate.
addition3 μL of a 0.0667 M solution of caffeine in DMSO was added to each reaction well using an SPT Labtech Mosquito® liquid handling robot
filtrationThe plates were then centrifuged for 15 to 20 seconds. · Keep liquid
aliquotFollowing centrifugation, 500 nL of the resultant mixture from each well was carefully dispensed into four 384-well analytical plates (Analytical Sales # 38435) using an SPT Labtech Mosquito® liquid handling robot. Each well of these analytical plates contained 30 μL of DMSO with 0.1% acetic acid, pre-dosed by OpenTrons, to facilitate analysis.

ORD record: ord-f6d61cd366c74bb8821a312d46947b74
Source dataset: High-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions
DOI: 10.1021/jacs.6c05959
Original link: View source

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customThe foil sealing tape was removed from the plate.
addition3 μL of a 0.0667 M solution of caffeine in DMSO was added to each reaction well using an SPT Labtech Mosquito® liquid handling robot
filtrationThe plates were then centrifuged for 15 to 20 seconds. · Keep liquid
aliquotFollowing centrifugation, 500 nL of the resultant mixture from each well was carefully dispensed into four 384-well analytical plates (Analytical Sales # 38435) using an SPT Labtech Mosquito® liquid handling robot. Each well of these analytical plates contained 30 μL of DMSO with 0.1% acetic acid, pre-dosed by OpenTrons, to facilitate analysis.

ORD record: ord-f6d61cd366c74bb8821a312d46947b74
Source dataset: High-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions
DOI: 10.1021/jacs.6c05959
Original link: View source

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