Morpholine → 4-(4-Trifluoromethylphenyl)morpholine
Reaction equation
C1COCCN1.FC(F)(F)c1ccc(Br)cc1>C1=[CH]2->[Ni]3(<-[CH](=CCC2)CC1)<-[CH]1=CCC[CH]->3=CCC1.CC(C)(C)[O-].COCCOCCOC.CS(C)=O.Cc1cc(C)c(N2C=[N+](c3c(C)cc(C)cc3C)CC2)c(C)c1.[Cl-].[Na+]>FC(F)(F)c1ccc(N2CCOCC2)cc1Participants
10
Reactant 2
Product 3
Reagents, catalysts & solvents 5
Conditions
- Temperature
- 60 °C
Workup
- customThe foil sealing tape was removed from the plate.
- addition3 μL of a 0.0667 M solution of caffeine in DMSO was added to each reaction well using an SPT Labtech Mosquito® liquid handling robot
- filtrationThe plates were then centrifuged for 15 to 20 seconds. · Keep liquid
- aliquotFollowing centrifugation, 500 nL of the resultant mixture from each well was carefully dispensed into four 384-well analytical plates (Analytical Sales # 38435) using an SPT Labtech Mosquito® liquid handling robot. Each well of these analytical plates contained 30 μL of DMSO with 0.1% acetic acid, pre-dosed by OpenTrons, to facilitate analysis.
Sources & evidence
- ORD record
- ord-d32dd1b039bf428586b910712789484e
- Source dataset
- High-throughput exploration of 50,688 Pd-, Ni- and Cu-catalysed C–N coupling reactions
- Original link
- View source
Reaction notes
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