Hydrogen Bromide → 2-Bromohexanoic acid, (S)-

(S)-2-aminohexanoic acid (FW 131.2, also known as L-norleucine) (1 g, 7.62 mmol), which is commercially available from Sigma Chemical Co at Sigmaaldrich.com, is dissolved in a mixture of HBr 48% (7.0 mL, 61 mmol) and H2O (10 mL). At 0° C., a solution of NaNO2 (1.7 g, 24 mmol) in H2O (5 mL) is added over a period of 30 min. The reaction is stirred for two hours. The reaction mixture is degassed in vacuo and extracted with EtOAc (2×20 mL). The extracts are washed with water (15 mL), dried (Na2SO4), filtered and evaporated to give (S)-2-bromohexanoic acid.

1. customThe reaction mixture is degassed in vacuo
2. extractionextracted with EtOAc (2×20 mL)
3. washThe extracts are washed with water (15 mL)
4. dry with materialdried (Na2SO4)
5. filtrationfiltered
6. customevaporated

ORD record

ord-c80dfe6010ea41a0adda434b542efe92

Source dataset

uspto-grants-2008_06

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07390789B2