2,3-Difluorobenzonitrile → 3-Fluoro-4-(2-fluoro-6-cyano-phenoxy)-phenylamine

HRID 13376

Reaction equation

HRID 13376 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([NH:9]C(=O)OC(C)(C)C)[CH:5]=[CH:6][C:7]=1[OH:8].[F:17][C:18]1[CH:23]=[CH:22][CH:21]=[C:20]([C:24]#[N:25])[C:19]=1F>>[F:1][C:2]1[CH:3]=[C:4]([NH2:9])[CH:5]=[CH:6][C:7]=1[O:8][C:19]1[C:20]([C:24]#[N:25])=[CH:21][CH:22]=[CH:23][C:18]=1[F:17]

Participants

3

Reactant 2

HCID 889352,3-DifluorobenzonitrileHCID 11708410tert-Butyl (3-Fluoro-4-hydroxyphenyl)carbamate

Product 1

HCID 231455073-Fluoro-4-(2-fluoro-6-cyano-phenoxy)-phenylamine

Procedure

The entitled compound was obtained in the same method as in Example 221 (step 1) or in accordance with the method or by combining it with an ordinary method but using tert-butyl (3-fluoro-4-hydroxy-phenyl)-carbamate obtained in Example 196 (step 1) and 1,2-difluoro-3-cyano-benzene.

Workup

  1. customThe entitled compound was obtained in the same method as in Example 221 (step 1) or in accordance with the method

Sources & evidence

ORD record
ord-414d8a4d43ff49a59592db1cbfed2ad3
Source dataset
uspto-grants-2010_06
Patent number
US07728025B2

Linked notes

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