Ethanol → HCID 178513350, compound
Reaction equation
[OH:1][NH2:2].[F:3][C:4]1[CH:34]=[CH:33][CH:32]=[CH:31][C:5]=1[O:6][C:7]1[C:21]([O:22][C:23]2[CH:24]=N[C:26]([C:29]#[N:30])=[CH:27][CH:28]=2)=[CH:20][C:10]2[NH:11][C:12]([C:14]3[CH:19]=[N:18][CH:17]=[CH:16][N:15]=3)=[N:13][C:9]=2[CH:8]=1.[CH2:35](O)C>>[F:3][C:4]1[CH:34]=[CH:33][CH:32]=[CH:31][C:5]=1[O:6][C:7]1[C:21]([O:22][C:23]2[CH:24]=[CH:35][C:26]([C:29](=[NH:30])[NH:2][OH:1])=[CH:27][CH:28]=2)=[CH:20][C:10]2[NH:11][C:12]([C:14]3[CH:19]=[N:18][CH:17]=[CH:16][N:15]=3)=[N:13][C:9]=2[CH:8]=1Participants
4
Procedure
0.5 ml of hydroxyamine (50% aqueous solution) was added to an ethanol (0.5 ml) solution of 6.0 mg of 5-(2-fluoro-phenoxy)-2-pyrazin-2-yl-6-(6-cyano-pyridin-3-yloxy)-1H-benzimidazole obtained in Example 252, and the reaction liquid was stirred at room temperature for 3 hours. Then, the solvent was evaporated away under reduced pressure to obtain the entitled compound as a pale yellow solid.