Acetonitrile → 4-Difluoromethoxymethyl-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester

Reaction equation

[CH3:1][O:2][C:3](=[O:4])[CH:5]1[N:6]([C:12](=[O:13])[O:14][C:15]([CH3:16])([CH3:17])[CH3:18])[CH2:7][CH:8]([CH2:10][OH:11])[CH2:9]1.[CH3:29][C:30]#[N:31].[Cu:32][I:33].[F:19][C:20]([S:21]([F:22])(=[O:23])=[O:24])([C:25]([OH:26])=[O:27])[F:28]>>[CH3:1][O:2][C:3](=[O:4])[CH:5]1[N:6]([C:12](=[O:13])[O:14][C:15]([CH3:16])([CH3:17])[CH3:18])[CH2:7][CH:8]([CH2:10][O:11][CH:20]([F:19])[F:28])[CH2:9]1

Participants

Reactant 4

HCID 6342Acetonitrile

HCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)

HCID 27375162,2-Difluoro-2-(fluorosulfonyl)acetic acid

HCID 235957531-(tert-Butyl) 2-methyl 4-(hydroxymethyl)pyrrolidine-1,2-dicarboxylate

Product 1

HCID 666204384-Difluoromethoxymethyl-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester

Sources & evidence

ORD record: ord-9913c6a79b8e45bca8a93dfd3c128935
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (9/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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