Dimethylamine → N,N-dimethyl-5-nitropyridin-2-amine
Reaction equation
Cl[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][N:3]=1.[CH3:11][NH:12][CH3:13].O>CN1C(=O)CCC1>[CH3:11][N:12]([CH3:13])[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][N:3]=1Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
2-Chloro-5-nitropyridine (1.0 eq) and dimethylamine (2 M in EtOH, 4.6 eq) in NMP were heated for 2 h at 100° C. The solution was then poured slowly into H2O. The filtrate that formed was filtered and dried to give 2-(dimethylamino)-5-nitropyridine.
Workup
- customThe filtrate that formed
- filtrationwas filtered
- customdried
Sources & evidence
- ORD record
- ord-34aaa92fa23d45839859c9f55903dc35
- Source dataset
- uspto-grants-2010_06
- Patent number
- US07728010B2
Reaction notes
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