Dimethylamine → N,N-dimethyl-5-nitropyridin-2-amine

HRID 13506

Reaction equation

HRID 13506 reaction equation
Cl[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][N:3]=1.[CH3:11][NH:12][CH3:13].O>CN1C(=O)CCC1>[CH3:11][N:12]([CH3:13])[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][N:3]=1

Participants

5

Reactant 3

HCID 674DimethylamineHCID 962WaterHCID 783082-Chloro-5-nitropyridine

Product 1

HCID 75707N,N-dimethyl-5-nitropyridin-2-amine

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Procedure

2-Chloro-5-nitropyridine (1.0 eq) and dimethylamine (2 M in EtOH, 4.6 eq) in NMP were heated for 2 h at 100° C. The solution was then poured slowly into H2O. The filtrate that formed was filtered and dried to give 2-(dimethylamino)-5-nitropyridine.

Workup

  1. customThe filtrate that formed
  2. filtrationwas filtered
  3. customdried

Sources & evidence

ORD record
ord-34aaa92fa23d45839859c9f55903dc35
Source dataset
uspto-grants-2010_06
Patent number
US07728010B2

Linked notes

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