Sodium ion → 4'-Amino-3'-fluoro[1,1'-biphenyl]-2-carbaldehyde

HRID 135152

Reaction equation

HRID 135152 reaction equation
[Br:12][c:13]1[cH:14][c:15]([F:20])[c:16]([NH2:17])[cH:18][cH:19]1.[C:21](=[O:22])([O-:23])[O-:24].[CH2:27]1[O:28][CH2:29][CH2:30][CH2:31]1.[CH:1](=[O:2])[c:3]1[c:4]([B:9]([OH:10])[OH:11])[cH:5][cH:6][cH:7][cH:8]1.[Na+:25].[Na+:26].[cH:32]1[cH:33][cH:34][c:35]([P:36]([Pd:37]([P:38]([c:39]2[cH:40][cH:41][cH:42][cH:43][cH:44]2)([c:45]2[cH:46][cH:47][cH:48][cH:49][cH:50]2)[c:51]2[cH:52][cH:53][cH:54][cH:55][cH:56]2)([P:57]([c:58]2[cH:59][cH:60][cH:61][cH:62][cH:63]2)([c:64]2[cH:65][cH:66][cH:67][cH:68][cH:69]2)[c:70]2[cH:71][cH:72][cH:73][cH:74][cH:75]2)[P:76]([c:77]2[cH:78][cH:79][cH:80][cH:81][cH:82]2)([c:83]2[cH:84][cH:85][cH:86][cH:87][cH:88]2)[c:89]2[cH:90][cH:91][cH:92][cH:93][cH:94]2)([c:95]2[cH:96][cH:97][cH:98][cH:99][cH:100]2)[c:101]2[cH:102][cH:103][cH:104][cH:105][cH:106]2)[cH:107][cH:108]1>>[CH:1](=[O:2])[c:3]1[c:4](-[c:13]2[cH:14][c:15]([F:20])[c:16]([NH2:17])[cH:18][cH:19]2)[cH:5][cH:6][cH:7][cH:8]1

Participants

7

Reactant 6

HCID 923Sodium ion2×HCID 8028TetrahydrofuranHCID 19660Carbonate IonHCID 1230504-Bromo-2-fluoroanilineHCID 2921892-Formylphenylboronic acidHCID 178420554HCID 178420554, compound

Product 1

HCID 222887634'-Amino-3'-fluoro[1,1'-biphenyl]-2-carbaldehyde

Sources & evidence

ORD record
ord-eb7a7ec1b33e4535b29c06c098cb358e
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Linked notes

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