Piperazine → 5-Methyl-2-(piperazin-1-yl)thiazole

Reaction equation

I[C:2]1[S:3][C:4]([CH3:7])=[CH:5][N:6]=1.[NH:8]1[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1>>[CH3:7][C:4]1[S:3][C:2]([N:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)=[N:6][CH:5]=1

Participants

Reactant 2

HCID 4837Piperazine

HCID 231545862-Iodo-5-methyl-1,3-thiazole

Product 1

HCID 211001905-Methyl-2-(piperazin-1-yl)thiazoleYield 32%

Procedure

Prepared in analogy to example 2 (b) from 2-iodo-5-methyl-thiazole and piperazine. The crude material was purified by chromatography (SiO2, methanol/dichloromethane) to yield the title compound as a yellow oil (yield 32%). MS (m/e): 184.3 (M+H+, 100%).

Workup

customThe crude material was purified by chromatography (SiO2, methanol/dichloromethane)

Sources & evidence

ORD record: ord-b611228972734f4c8a8d171ece5f94ad
Source dataset: uspto-grants-2007_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07220744B2

Reaction notes

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