HCID 21104706, compound → HCID 21104576, compound
Reaction equation
[O:1]1[C:6]2[CH:7]=[CH:8][C:9]([CH2:11][NH:12][CH2:13][C:14]3[CH2:19][N:18](NC(OC(C)(C)C)=O)[CH2:17][CH2:16][CH:15]=3)=[CH:10][C:5]=2[O:4][CH2:3][CH2:2]1>C(O)(C(F)(F)F)=O>[O:1]1[C:6]2[CH:7]=[CH:8][C:9]([CH2:11][NH:12][CH2:13][C:14]3[CH2:19][NH:18][CH2:17][CH2:16][CH:15]=3)=[CH:10][C:5]=2[O:4][CH2:3][CH2:2]1Participants
3
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Procedure
A solution of tert-butyl 5-{[(2,3-dihydro-benzo[1,4]-dioxin-6-ylmethyl)-amino]-methyl}-3,6-dihydro-2H-pyridine-1-carbamate (0.16 g, 0.44 mmol) in TFA (3 ml) was stirred at room temperature for 30 minutes, concentrated and taken up in saturated bicarbonate solution (30 ml) and dichloromethane (30 ml). The aqueous phase was extracted with dichloromethane (2×30 ml) and the combined organic phases were washed with saturated sodium chloride solution, dried over MgSO4 and concentrated.
Workup
- concentrationconcentrated
- extractionThe aqueous phase was extracted with dichloromethane (2×30 ml)