Butyl bromide → 4-Butoxy-3-methoxybenzoic acid

Reaction equation

[OH:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8]C)=[O:7])=[CH:4][C:3]=1[O:12][CH3:13].Br[CH2:15][CH2:16][CH2:17][CH3:18]>>[CH2:15]([O:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([OH:8])=[O:7])=[CH:4][C:3]=1[O:12][CH3:13])[CH2:16][CH2:17][CH3:18]

Participants

Reactant 2

HCID 8002Butyl bromide

HCID 19844Methyl Vanillate

Product 1

HCID 22279804-Butoxy-3-methoxybenzoic acid

Procedure

Methyl 4-hydroxy-3-methoxybenzoate was alkylated with bromobutane by method H and hydrolyzed by method P-a. This resulted in the product with the molecular weight of 224.26 (C12H16O4); MS (ESI): 225 (M+H+).

Workup

customThis resulted in the product with the molecular weight of 224.26 (C12H16O4)

Sources & evidence

ORD record: ord-e4bf9e568ef040ff9ce3415309294667
Source dataset: uspto-grants-2007_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07223788B2

Reaction notes

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