Dichloromethane → [5-chloro-1'-[(5-methyl-3-phenylisoxazol-4-yl)methyl]-2,2'-dioxospiro[indole-3,3'-pyrrolidin]-1(2H)-yl]acetic acid

Reaction equation

[Cl:1][c:2]1[cH:3][c:4]2[c:8]([cH:9][cH:10]1)[N:7]([CH2:11][C:12](=[O:13])[O:14][C:15]([CH3:16])([CH3:17])[CH3:18])[C:6](=[O:19])[C:5]21[C:20](=[O:37])[N:21]([CH2:24][c:25]2[c:26](-[c:31]3[cH:32][cH:33][cH:34][cH:35][cH:36]3)[n:27][o:28][c:29]2[CH3:30])[CH2:22][CH2:23]1.[Cl:45][CH2:46][Cl:47].[OH:38][C:39]([C:40]([F:41])([F:42])[F:43])=[O:44]>>[Cl:1][c:2]1[cH:3][c:4]2[c:8]([cH:9][cH:10]1)[N:7]([CH2:11][C:12](=[O:13])[OH:14])[C:6](=[O:19])[C:5]21[C:20](=[O:37])[N:21]([CH2:24][c:25]2[c:26](-[c:31]3[cH:32][cH:33][cH:34][cH:35][cH:36]3)[n:27][o:28][c:29]2[CH3:30])[CH2:22][CH2:23]1