Ethanol → 2-Amino-4-ethoxy-6-(5-methyl-furan-2-yl)-pyrimidine-5-carbonitrile
Reaction equation
[NH2:1][C:2]1[N:7]=[C:6](S(C)=O)[C:5]([C:11]#[N:12])=[C:4]([C:13]2[O:14][C:15]([CH3:18])=[CH:16][CH:17]=2)[N:3]=1.[CH2:19]([OH:21])[CH3:20].C1CCN2C(=NCCC2)CC1>COCCOC>[NH2:1][C:2]1[N:7]=[C:6]([O:21][CH2:19][CH3:20])[C:5]([C:11]#[N:12])=[C:4]([C:13]2[O:14][C:15]([CH3:18])=[CH:16][CH:17]=2)[N:3]=1Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
From 2-amino-4-methanesulfinyl-6-(5-methyl-furan-2-yl)-pyrimidine-5-carbonitrile, ethanol and DBU in DME. ES-MS m/e (%): 245 (M+H+, 100), 217 ([M+H—CH2═CH2]+, 80).
Sources & evidence
- ORD record
- ord-778e0f9a11df4bc493647c64c2f27660
- Source dataset
- uspto-grants-2003_07
- Patent number
- US06586441B2
Reaction notes
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