1,8-Diazabicyclo(5.4.0)undec-7-ene → 2-Amino-4-pyrazol-1-yl-6-[(quinolin-2-yl-methyl)-amino]-pyrimidine-5-carbonitrile

HRID 1356161

Reaction equation

HRID 1356161 reaction equation
[NH2:1][C:2]1[N:7]=[C:6](S(C)=O)[C:5]([C:11]#[N:12])=[C:4]([N:13]2[CH:17]=[CH:16][CH:15]=[N:14]2)[N:3]=1.Cl.[N:19]1[C:28]2[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=2)[CH:22]=[CH:21][C:20]=1[CH2:29][NH2:30].C1CCN2C(=NCCC2)CC1>COCCOC>[NH2:1][C:2]1[N:3]=[C:4]([N:13]2[CH:17]=[CH:16][CH:15]=[N:14]2)[C:5]([C:11]#[N:12])=[C:6]([NH:30][CH2:29][C:20]2[CH:21]=[CH:22][C:23]3[C:28](=[CH:27][CH:26]=[CH:25][CH:24]=3)[N:19]=2)[N:7]=1

Participants

5

Reactant 3

HCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneHCID 185075202-Amino-4-methanesulfinyl-6-pyrazol-1-yl-pyrimidine-5-carbonitrileHCID 185075291-(Quinolin-2-yl)methanamine--hydrogen chloride (1/1)

Product 1

HCID 185075792-Amino-4-pyrazol-1-yl-6-[(quinolin-2-yl-methyl)-amino]-pyrimidine-5-carbonitrile

Reagents, catalysts & solvents 1

HCID 80711,2-DimethoxyethaneSolvent

Procedure

From 2-amino-4-methanesulfinyl-6-pyrazol-1-yl-pyrimidine-5-carbonitrile, C-quinolin-2-yl-methylamine hydrochloride and DBU in DME. ES-MS m/e (%): 343 (M+H+, 100).

Sources & evidence

ORD record
ord-4fa9b08c5edb4ffe80d7b6ecb60e176c
Source dataset
uspto-grants-2003_07
Patent number
US06586441B2

Linked notes

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