2,2-Diphenylacetyl chloride → N-(5-trifluoromethyl-[1,3,4]oxadiazol-2-yl)-2,2-diphenyl-acetamide

HRID 1358442

Reaction equation

HRID 1358442 reaction equation
[F:1][C:2]([F:10])([F:9])[C:3]1[O:7][C:6]([NH2:8])=[N:5][N:4]=1.[C:11]1([CH:17]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[C:18](Cl)=[O:19])[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>>[F:1][C:2]([F:10])([F:9])[C:3]1[O:7][C:6]([NH:8][C:18](=[O:19])[CH:17]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)=[N:5][N:4]=1

Participants

3

Reactant 2

HCID 746372,2-Diphenylacetyl chlorideHCID 5226305-(Trifluoromethyl)-1,3,4-oxadiazol-2-amine

Product 1

HCID 22661060N-(5-trifluoromethyl-[1,3,4]oxadiazol-2-yl)-2,2-diphenyl-acetamide

Procedure

The title compound, white solid, m.p. 149-150° C. and MS: m/e=347.2 (M+) was prepared in accordance with the general method of example 44a from 5-trifluoromethyl[1,3,4]oxadiazol-2-ylamine and 2,2-diphenylacetic acid chloride.

Sources & evidence

ORD record
ord-5f8b622d2fad4a10a4be0a3f419ff962
Source dataset
uspto-grants-2003_07
Patent number
US06596743B2

Linked notes

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