Oxalyl chloride → (3,5-Dibromo-4-methoxyphenyl)acetylchloride
Reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([CH2:11][C:12]([OH:14])=O)[CH:5]=[C:6]([Br:10])[C:7]=1[O:8][CH3:9].C(Cl)(=O)C([Cl:18])=O>C1C=CC=CC=1>[Br:1][C:2]1[CH:3]=[C:4]([CH2:11][C:12]([Cl:18])=[O:14])[CH:5]=[C:6]([Br:10])[C:7]=1[O:8][CH3:9]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
3,5-Dibromo-4-methoxyphenyl acetic acid (3.239 g, 0.01 mol) was refluxed with oxalyl chloride (2.03 g, 0.016 mol) in anhydrous benzene (50 mL) for 6 h. The reaction mixture was cooled, concentrated and evaporated 3 times with benzene to give an oil which was used for further reaction.
Workup
- temperatureThe reaction mixture was cooled
- concentrationconcentrated
- customevaporated 3 times with benzene
- customto give an oil which
- customwas used for further reaction
Sources & evidence
- ORD record
- ord-f40e8dfb090a4d0ab319ddc7b87fad7f
- Source dataset
- uspto-grants-2003_07
- Patent number
- US06596734B1
Reaction notes
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