1,5-Dimethyl-1H-pyrazole-3-carboxamide → 1,5-dimethyl-1H-pyrazole-3-carbonitrile
Reaction equation
[CH3:1][N:2]1[C:6]([CH3:7])=[CH:5][C:4]([C:8]([NH2:10])=O)=[N:3]1>P(Cl)(Cl)(Cl)=O>[CH3:1][N:2]1[C:6]([CH3:7])=[CH:5][C:4]([C:8]#[N:10])=[N:3]1Participants
3
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Procedure
The method described in Part E of Examples 1 through 4 was used to treat 1,5-dimethyl-1H-pyrazole-3-carboxamide (5.0 g, 36 mmol) with phosphorous oxychloride (20 mL) to afford 3.9 g of 1,5-dimethyl-1H-pyrazole-3-carbonitrile. A small portion was recrystallized from hexane to provide the following data.
Sources & evidence
- ORD record
- ord-5b96732276d242a4918f0753e1b7f623
- Source dataset
- uspto-grants-2011_02
- Patent number
- US07879849B2
Reaction notes
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