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Piperidine → HCID 59170818, compound

HRID 1362653
Notes
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Reaction equation

HRID 1362653 reaction equation
N1CCCCC1.[CH3:7][O:8][C:9]1[CH:10]=[C:11]([CH:14]=[CH:15][C:16]=1[N:17]1[CH:21]=[C:20]([CH3:22])[N:19]=[CH:18]1)[CH:12]=O.[CH3:23][O:24][C:25]1[CH:30]=[CH:29][C:28]([N:31]2[C:35](=[O:36])[CH2:34][NH:33][C:32]2=[S:37])=[CH:27][CH:26]=1>C(O)C>[CH3:7][O:8][C:9]1[CH:10]=[C:11]([CH:14]=[CH:15][C:16]=1[N:17]1[CH:21]=[C:20]([CH3:22])[N:19]=[CH:18]1)/[CH:12]=[C:34]1/[C:35](=[O:36])[N:31]([C:28]2[CH:27]=[CH:26][C:25]([O:24][CH3:23])=[CH:30][CH:29]=2)[C:32](=[S:37])[NH:33]/1
ParticipantsProcedureWorkupSources & evidenceReaction notes

Participants

5

Reactant 3

HCID 8082PiperidineHCID 757480Hydantoin, 3-(p-methoxyphenyl)-2-thio-HCID 272824453-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzaldehyde

Product 1

HCID 59170818HCID 59170818, compoundYield 47%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Piperidine (0.019 mL) was added to an ethanol (2 mL) solution of 3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzaldehyde (20 mg) obtained in Example 1 and 3-(4-methoxyphenyl)-2-thioxoimidazolidine-4-one (21 mg), and heat-refluxing of the reaction solution was carried out for 12 hours. The reaction solution was allowed to be cooled to room temperature and the solid deposited was separated by filtering, and 18 mg (47%) of the title compound was obtained by washing with ethanol and ether. The physical properties of the compound are as follows.

Workup

  1. temperatureheat-refluxing of the reaction solution
  2. customthe solid deposited was separated
  3. filtrationby filtering

Sources & evidence

ORD record
ord-f0055b615455456b94c7c78ecc79013d
Source dataset
uspto-grants-2011_02
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US07880009B2

Reaction notes

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On this pageParticipantsProcedureWorkupSources & evidenceReaction notes