Cesium carbonate → (S)-(+)-N-(3-(6-(4-(2-(Dimethylamino)-1-(isopropyl(methyl)amino)-2-oxoethyl)phenylamino)-4-methyl-5-oxo-4,5-dihydropyrazin-2-yl)-2-methylphenyl)-4,5,6,7-tetrahydrobenzo[b]thiophene-2-carboxamide

Reaction equation

[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C@H:8]([N:14]([CH:16]([CH3:18])[CH3:17])[CH3:15])[C:9]([N:11]([CH3:13])[CH3:12])=[O:10])=[CH:4][CH:3]=1.Br[C:20]1[C:21](=[O:46])[N:22]([CH3:45])[CH:23]=[C:24]([C:26]2[C:27]([CH3:44])=[C:28]([NH:32][C:33]([C:35]3[S:39][C:38]4[CH2:40][CH2:41][CH2:42][CH2:43][C:37]=4[CH:36]=3)=[O:34])[CH:29]=[CH:30][CH:31]=2)[N:25]=1.C(=O)([O-])[O-].[Cs+].[Cs+].CC1(C)C2C(=C(P(C3C=CC=CC=3)C3C=CC=CC=3)C=CC=2)OC2C(P(C3C=CC=CC=3)C3C=CC=CC=3)=CC=CC1=2>C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.[Pd].[Pd].O1CCOCC1>[CH3:13][N:11]([CH3:12])[C:9](=[O:10])[C@H:8]([C:5]1[CH:6]=[CH:7][C:2]([NH:1][C:20]2[C:21](=[O:46])[N:22]([CH3:45])[CH:23]=[C:24]([C:26]3[C:27]([CH3:44])=[C:28]([NH:32][C:33]([C:35]4[S:39][C:38]5[CH2:40][CH2:41][CH2:42][CH2:43][C:37]=5[CH:36]=4)=[O:34])[CH:29]=[CH:30][CH:31]=3)[N:25]=2)=[CH:3][CH:4]=1)[N:14]([CH:16]([CH3:18])[CH3:17])[CH3:15]