Hydrochloric Acid → HCID 66958569, compound
Reaction equation
Cl.[Cl:2][CH2:3][C:4]1[N:5]([CH2:17][CH2:18][CH2:19][NH:20]C(=O)OC(C)(C)C)[C:6]2[C:15]3[N:14]=[CH:13][CH:12]=[CH:11][C:10]=3[N:9]=[CH:8][C:7]=2[N:16]=1>CO>[ClH:2].[Cl:2][CH2:3][C:4]1[N:5]([CH2:17][CH2:18][CH2:19][NH2:20])[C:6]2[C:15]3[N:14]=[CH:13][CH:12]=[CH:11][C:10]=3[N:9]=[CH:8][C:7]=2[N:16]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
Concentrated hydrochloric acid (20 mL) was added to a suspension of tert-butyl 3-[2-(chloromethyl)-1H-imidazo[4,5-c][1,5]naphthyridin-1-yl]propylcarbamate (12.55 g, 33.4 mmol) in methanol (135 mL). The resulting yellow solution was stirred for 48 hours and the liquid was removed via filtration. The resulting solid filter cake was dried overnight in a vacuum, oven at 40° C. to afford 9.62 g of 3-[2-(chloromethyl)-1H-imidazo[4,5-c]-1,5-naphthyridin-1-yl]propylamine hydrochloride as a pale yellow solid.