Oxalyl chloride → (2,5-Dimethoxyphenyl)acetyl chloride

HRID 1364528

Reaction equation

HRID 1364528 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([O:9][CH3:10])=[CH:5][C:4]=1[CH2:11][C:12]([OH:14])=O.C(Cl)(=O)C([Cl:18])=O>C(Cl)Cl>[O:2]([C:3]1[CH:8]=[CH:7][C:6]([O:9][CH3:10])=[CH:5][C:4]=1[CH2:11][C:12]([Cl:18])=[O:14])[CH3:1]

Participants

4

Reactant 2

HCID 65578Oxalyl chlorideHCID 744692,5-Dimethoxyphenylacetic acid

Product 1

HCID 596088(2,5-Dimethoxyphenyl)acetyl chloride

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 196 mg (1.00 mmol) of (2,5-dimethoxyphenyl)acetic acid in 3 mL of CH2Cl2 was added 100 μL of oxalyl chloride. The mixture was stirred at ambient temperature for 1 hour then concentrated under reduced pressure to a thick liquid.

Workup

  1. concentrationthen concentrated under reduced pressure to a thick liquid

Sources & evidence

ORD record
ord-5f39d295ad2548daab8b070d6410a14a
Source dataset
uspto-grants-2011_02
Patent number
US07888374B2

Linked notes

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