Methylamine → 4-((Methylamino)methyl)thiazol-2-amine
Reaction equation
Cl[CH2:2][C:3]1[N:4]=[C:5]([NH2:8])[S:6][CH:7]=1.[CH3:9][NH2:10]>>[CH3:9][NH:10][CH2:2][C:3]1[N:4]=[C:5]([NH2:8])[S:6][CH:7]=1Participants
3
Procedure
4-(Chloromethyl)-1,3-thiazol-2-amine (490 mg, 2.65 mmol) was stirred in 40% aqueous methylamine (25 ml) overnight. The reaction mixture was evaporated. The residue was diluted with 95:5 dichloromethane/methanol (25 ml), was dried over sodium sulfate, was filtered and was evaporated to provide 4-[(methylamino)methyl]-1,3-thiazol-2-amine that was used without purification. LCMS: (M+H)+: 144.0.
Workup
- customThe reaction mixture was evaporated
- additionThe residue was diluted with 95:5 dichloromethane/methanol (25 ml)
- dry with materialwas dried over sodium sulfate
- filtrationwas filtered
- customwas evaporated
Sources & evidence
- ORD record
- ord-bc4cbc615a75492997445548ce2f3fe3
- Source dataset
- uspto-grants-2011_02
- Patent number
- US07893056B2
Reaction notes
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