1-Methylpiperazine → HCID 21071294, compound
Reaction equation
Cl[CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:7]=[C:8]([CH2:12][C:13]([OH:15])=[O:14])[CH:9]=[CH:10][CH:11]=1.[CH3:16][N:17]1[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]1>O>[CH3:16][N:17]1[CH2:22][CH2:21][N:20]([CH2:2][CH2:3][CH2:4][O:5][C:6]2[CH:7]=[C:8]([CH2:12][C:13]([OH:15])=[O:14])[CH:9]=[CH:10][CH:11]=2)[CH2:19][CH2:18]1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 60 °C
Procedure
A mixture of 3-(3-chloro-propoxy)-phenylacetic acid (0.5 g, 2.2 mmol) and N-methylpiperazine (1.9 mL) was heated at 60° C. overnight. The reaction was diluted with water and purified by preparative HPLC to give the product as a clear gel. (0.6 g, 94%).