Hydrochloric Acid → HCID 22607995, compound
Reaction equation
[C:1]1([S:7][C:8]2[CH:9]=[C:10]([CH:14]3OCC[O:15]3)[CH:11]=[CH:12][CH:13]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl>C(#N)C>[C:1]1([S:7][C:8]2[CH:9]=[C:10]([CH:11]=[CH:12][CH:13]=2)[CH:14]=[O:15])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
Combine 2-(3-phenylsulfanylphenyl)-[1,3]-dioxolane (0.3 g, 1.1 mmol) and acetonitrile (8.0 ml) add a solution of hydrochloric acid (1N, 2.0 ml). After 18 hours, concentrate in vacuum to remove most of the acetonitrile, dilute with water and extract with ether. Combine the organic extracts and wash once with saturated sodium bicarbonate, then with brine. Dry (Na2SO4) the organics, filter, and concentrated to give the title compound.
Workup
- concentrationconcentrate in vacuum
- customto remove most of the acetonitrile
- additiondilute with water
- extractionextract with ether
- washwash once with saturated sodium bicarbonate
- dry with materialDry (Na2SO4) the organics,
- filtrationfilter
- concentrationconcentrated
Sources & evidence
- ORD record
- ord-3a81f9daeeb04bad8c589b50f3f5a9b8
- Source dataset
- uspto-grants-2007_01
- Patent number
- US07157488B2
Reaction notes
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