Hydrogen Bromide → HCID 23020487, compound
Reaction equation
Br.[NH2:2][C:3]1[N:8]([CH3:9])[C:7](=[O:10])[C:6]([C:11]2[CH:12]=[N:13][C:14]([O:17]C)=[CH:15][CH:16]=2)=[C:5]([C:19]2[CH:24]=[CH:23][CH:22]=[C:21]([F:25])[CH:20]=2)[N:4]=1>C(O)(=O)C>[NH2:2][C:3]1[N:8]([CH3:9])[C:7](=[O:10])[C:6]([C:11]2[CH:16]=[CH:15][C:14](=[O:17])[NH:13][CH:12]=2)=[C:5]([C:19]2[CH:24]=[CH:23][CH:22]=[C:21]([F:25])[CH:20]=2)[N:4]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
In a mixture solution of acetic acid and 48% hydrogen bromide, 2-amino-6-(3-fluorophenyl)-5-(6-methoxy-3-pyridyl)-3-methyl-3,4-dihydro-4-pyrimidinone was stirred at 100° C. for 2 hours. After cooling, the reaction solution was basified and washed with ethyl acetate. The aqueous layer was neutralized with diluted hydrochloric acid, and the resulting solid was collected by filtration, to give the title compound.