Hydrogen Peroxide → 1,2-Epoxycyclooctane

Temperature

30 °C

Hydrogen peroxide (30%, 2 ml) was added to a mixture of the catalyst from Example 48 (0.04 g) and cis-cyclooctene (1.4 g, 11.5 mmol) in tert-butanol (10 ml) at 30° C. under an atmosphere of nitrogen. The reaction mixture was stirred at 30° C. for 48 h under nitrogen. The catalyst was filtered off and washed well with ether (80 ml). The combined organic layers were washed well with water (2×40 ml) and then dried over magnesium sulphate. After filtration the solvent was removed under reduced pressure—20° C. at 50 mm of Hg—to afford 9-oxabicyclo[6.1.0] nonane as a white solid (0.95 g, 65%). M.p. 51° C., lit. m.p. 53-56° C.

1. filtrationThe catalyst was filtered off
2. washwashed well with ether (80 ml)
3. washThe combined organic layers were washed well with water (2×40 ml)
4. dry with materialdried over magnesium sulphate
5. filtrationAfter filtration the solvent
6. customwas removed under reduced pressure—20° C. at 50 mm of Hg—

ORD record

ord-a3737b6754ce46ea9ec4a4e839d3ab7b

Source dataset

uspto-grants-2010_06

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07728159B2