Potassium Cyanide → 2-Bromo-4-methoxy-5-(1-methylethoxy)benzene Acetonitrile
Reaction equation
[Br:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[C:5]([O:10][CH:11]([CH3:13])[CH3:12])=[CH:4][C:3]=1[CH2:14]Cl.[C-:16]#[N:17].[K+]>CS(C)=O>[Br:1][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[C:5]([O:10][CH:11]([CH3:13])[CH3:12])=[CH:4][C:3]=1[CH2:14][C:16]#[N:17]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
1-Bromo-2-(chloromethyl)-5-methoxy-4-(1-methylethoxy)benzene (7.00 g, 23.8 mmol) and potassium cyanide (1.70 g, 26.1 mmol, freshly ground) are stirred in absolute DMSO (70 ml) for 12 hours at room temperature.
Sources & evidence
- ORD record
- ord-31349d0fcb8b4b29a31ea9c10970201f
- Source dataset
- uspto-grants-2007_01
- Patent number
- US07166588B2
Reaction notes
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