Methylamine → 3-Bromo-1-(2'hydroxyethyl)-5-methylamino-4-nitropyrazole

HRID 1376884

Reaction equation

HRID 1376884 reaction equation
[Br:1][C:2]1[C:6]([N+:7]([O-:9])=[O:8])=[C:5](Br)[N:4]([CH2:11][CH2:12][OH:13])[N:3]=1.[CH3:14][NH2:15]>O>[Br:1][C:2]1[C:6]([N+:7]([O-:9])=[O:8])=[C:5]([NH:15][CH3:14])[N:4]([CH2:11][CH2:12][OH:13])[N:3]=1

Participants

4

Reactant 2

HCID 6329MethylamineHCID 130072363,5-Dibromo-1-(2'-hydroxyethyl)-4-nitropyrazole

Product 1

HCID 229186273-Bromo-1-(2'hydroxyethyl)-5-methylamino-4-nitropyrazoleYield 91%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

3.15 g (10 mmoles) of 3,5-dibromo-1-(2'-hydroxyethyl)-4-nitropyrazole are heated in 70 ml of a 30-percent solution of methylamine in water for 1 hour at 60° C. After cooling, the product precipitates in the form of bright yellow crystals with a melting point of 158° to 160° C. 2.4 g (91 percent of theory) of 3-bromo-1-(2'hydroxyethyl)-5-methylamino-4-nitropyrazole are obtained.

Workup

  1. temperatureAfter cooling
  2. customthe product precipitates in the form of bright yellow crystals with a melting point of 158° to 160° C

Sources & evidence

ORD record
ord-248d8ac453d94604bf63cb5067b16b07
Source dataset
uspto-grants-1997_09
Patent number
US05663366

Linked notes

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