Hydrochloric Acid → HCID 70078313, compound
Reaction equation
[CH2:1]([N:5]([CH2:10][C:11]1[O:15][N:14]=[C:13]([C:16]2[N:17]=[CH:18][N:19]3[C:25]4[CH:26]=[CH:27][C:28]([F:30])=[CH:29][C:24]=4[C:23](=[O:31])[N:22]([CH3:32])[CH2:21][C:20]=23)[N:12]=1)[CH2:6][CH2:7][CH2:8][CH3:9])[CH2:2][CH2:3][CH3:4].[ClH:33]>C(O)C>[ClH:33].[CH2:1]([N:5]([CH2:10][C:11]1[O:15][N:14]=[C:13]([C:16]2[N:17]=[CH:18][N:19]3[C:25]4[CH:26]=[CH:27][C:28]([F:30])=[CH:29][C:24]=4[C:23](=[O:31])[N:22]([CH3:32])[CH2:21][C:20]=23)[N:12]=1)[CH2:6][CH2:7][CH2:8][CH3:9])[CH2:2][CH2:3][CH3:4]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
1.17 g (0.0027 mol) of 3-(5-dibutylaminomethyl-1,2,4-oxadiazol-3-yl)-8-fluoro-5-methyl-5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepin-6-one in 30 ml of ethanol were treated with 0.65 ml (0.0031 mol) of 3.7N ethanolic hydrochloric acid. The solvent was freed completely from solvent and the residue was recrystallized from acetone. There was obtained 0.87 g (69%) of 3-(5-dibutylaminomethyl-1,2,4-oxadiazol-3-yl)-8-fluoro-5-methyl-5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepin-6- one hydrochloride as white crystals; m.p. 183°-185°.