Hydrochloric Acid → Phenyl-3-chlorobenzoate
Reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][CH:10]=1)[C:5](Cl)=[O:6].[C:11]1([OH:17])[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1.N1C=CC=CC=1.Cl>C1(C)C=CC=CC=1>[C:11]1([O:17][C:5](=[O:6])[C:4]2[CH:8]=[CH:9][CH:10]=[C:2]([Cl:1])[CH:3]=2)[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1Participants
6
Reactant 4
Product 1
Reagents, catalysts & solvents 1
Procedure
Phenyl-3-chlorobenzoate is prepared by reacting 3-chlorobenzoyl chloride with phenol in toluene with some pyridine (1 mol equivalent per acid chloride) to trap the HCl that evolves. After aqueous extraction of the pyridinium salt and any excess starting materials, the product is crystallized from the toluene solution.
Workup
- extractionAfter aqueous extraction of the pyridinium salt
- customany excess starting materials, the product is crystallized from the toluene solution
Sources & evidence
- ORD record
- ord-a72bec2b35324f4898b73d1b1039779c
- Source dataset
- uspto-grants-1997_09
- Patent number
- US05670564
Reaction notes
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