1-Isocyanato-4-methoxybenzene → Carbamic acid,(4-methoxyphenyl)-,1h-indol-7-yl ester

HRID 1380080

Reaction equation

HRID 1380080 reaction equation
[OH:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:10]=1[NH:9][CH:8]=[CH:7]2.[CH3:11][O:12][C:13]1[CH:18]=[CH:17][C:16]([N:19]=[C:20]=[O:21])=[CH:15][CH:14]=1>C(OCC)C.C(N(CC)CC)C>[CH3:11][O:12][C:13]1[CH:18]=[CH:17][C:16]([NH:19][C:20](=[O:21])[O:1][C:2]2[CH:3]=[CH:4][CH:5]=[C:6]3[C:10]=2[NH:9][CH:8]=[CH:7]3)=[CH:15][CH:14]=1

Participants

5

Reactant 2

HCID 794431-Isocyanato-4-methoxybenzeneHCID 27376517-Hydroxyindole

Product 1

HCID 20242122Carbamic acid,(4-methoxyphenyl)-,1h-indol-7-yl ester

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 8471TriethylamineSolvent

Procedure

To a solution of 7-hydroxyindole (0.7 g.) in ethyl ether (25 ml) and triethylamine (1 ml) is added 0.8 g. 4-methoxyphenyl isocyanate (Aldrich 23860-0). The reaction is stirred for 3 days at room temperature. The solvent is removed in vacuo and the remaining oil is purified by HPLC on silica gel.

Workup

  1. customThe solvent is removed in vacuo
  2. customthe remaining oil is purified by HPLC on silica gel

Sources & evidence

ORD record
ord-0d3d79ab1fce4551a70c6636a84fdf01
Source dataset
uspto-grants-1986_04
Patent number
US04579865

Linked notes

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