Potassium Carbonate → 9-(1,3-Di-n-octanoyloxy-2-propoxymethyl)guanine

HRID 1381765Notes

Reaction equation

HRID 1381765 reaction equation
Cl.[C:2]([O:11][CH2:12][CH:13]([O:25][CH2:26][N:27]1[CH:35]=[N:34][C:33]2[C:32](=[O:36])[NH:31][C:30]([NH2:37])=[N:29][C:28]1=2)[CH2:14][O:15][C:16](=[O:24])[CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH3:23])(=[O:10])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH3:9].C(=O)([O-])[O-].[K+].[K+]>CCOCC>[C:2]([O:11][CH2:12][CH:13]([O:25][CH2:26][N:27]1[CH:35]=[N:34][C:33]2[C:32](=[O:36])[NH:31][C:30]([NH2:37])=[N:29][C:28]1=2)[CH2:14][O:15][C:16](=[O:24])[CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH3:23])(=[O:10])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH3:9]

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 136332160HCID 136332160, compound

Product 1

HCID 1363321599-(1,3-Di-n-octanoyloxy-2-propoxymethyl)guanine

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

1.0 g of 9-(1,3-di-n-octanoyloxy-2 propoxymethyl)guanine HCl suspended in 50 ml of ether is stirred with a twofold stoichiometric excess of dilute aqueous potassium carbonate solution until the salt is completely dissolved. The organic layer is then separated, washed twice with water, dried over magnesium sulfate and evaporated to yield 9-(1,3-di-n-octanoyloxy-2-propoxy methyl)guanine as the free base.

Workup

  1. dissolutionis completely dissolved
  2. customThe organic layer is then separated
  3. washwashed twice with water
  4. dry with materialdried over magnesium sulfate
  5. customevaporated

Sources & evidence

ORD record
ord-db6385784dc245b09772589e1cf94e65
Source dataset
uspto-grants-1989_02
Patent number
US04803271

Reaction notes

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