Methane → 1,3-Dimethylpyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione
Reaction equation
Cl[C:2]1[C:11]2[C:10](=[O:12])[N:9]([CH3:13])[C:8](=[O:14])[N:7]([CH3:15])[C:6]=2[N:5]=[CH:4][CH:3]=1.C>CO.[Pd]>[CH3:15][N:7]1[C:6]2[N:5]=[CH:4][CH:3]=[CH:2][C:11]=2[C:10](=[O:12])[N:9]([CH3:13])[C:8]1=[O:14]Participants
5
Procedure
0.34 g of Compound 1 was dissolved in 100 ml of methanol and reduced in the presence of Pd-C. Activated charcoal powder was added, and the solution was heated and filtered. The filtrate was distilled under reduced pressure and ethanol was added thereto. The resulting crude crystals were separated from the solution by the filtration and recrystallized from ethanol to give 0.24 g of 1,3-dimethylpyrido[2,3-d]pyrimidine-2,4-dione (Compound 2).
Workup
- temperaturethe solution was heated
- filtrationfiltered
- distillationThe filtrate was distilled under reduced pressure and ethanol
- additionwas added
- customThe resulting crude crystals were separated from the solution by the filtration
- customrecrystallized from ethanol
Sources & evidence
- ORD record
- ord-673b93bf2ef044958d4e1e291895f078
- Source dataset
- uspto-grants-1989_02
- Patent number
- US04808587
Reaction notes
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